Mpox is no longer a Public Health Emergency of International Concern, following the Africa CDC’s decision to revoke this status, based on the recommendation of its Emergency Consultative Group. This marks an important step forward for the continent and reflects stronger preparedness and coordination across countries.

The emergency was declared in August 2024 after mpox cases rose sharply to more than 80,000 suspected infections and 1,340 deaths, mostly in the Democratic Republic of Congo. Limited access to vaccines, diagnostics and treatments had left African countries especially vulnerable to the outbreak.

In response, Africa CDC led a coordinated effort that mobilised over US$1 billion, strengthened community‑based surveillance, expanded laboratory and genomic capacity, delivered more than five million vaccine doses to 16 countries, and advanced joint research with thousands of scientists. These actions helped reduce suspected cases by 40%, confirmed cases by 60%, and sharply lowered the fatality rate.

With the emergency phase over, Africa CDC is shifting focus to long‑term control and eventual elimination. Mpox remains present in some areas, so continued vigilance is needed. A new Mpox Transition Roadmap will support countries in maintaining strong surveillance, vaccination, and research systems, while also helping shape broader efforts to improve health security across Africa.