South Sudan’s sustained cholera outbreak response has reduced new cases and prevented around 94 000 deaths since the confirmation of the outbreak more than two years ago in September 2024.  

Working with government departments, World Health Organization (WHO) and partners, the Ministry of Health in South Sudan activated a multisectoral response within 24 hours of outbreak confirmation. The result of which is a drop in the number of new cholera cases from an average of 1000 at the peak of the outbreak in December 2024 to 114 in the last week of September 2025. The number of affected counties has dropped from 55 to 12 in the same reporting period and the outbreak is now restricted to 29 out of 517 payams (administrative divisions).  

At the outset, the Public Health Emergency Operations Centre reactivated national rapid response teams. These seven-member teams were deployed to counties to conduct investigations, assess county capacity to manage the outbreak and recommend additional capacity to be filled with surge deployments.