When high quality health information is not available and questions and concerns go unaddressed, low quality health information or misinformation can quickly spread across communities and impact people’s health decisions. In response to the need to understand the  health information environment and help health workers better communicate and engage with the public to encourage healthy behaviors, WHO and UNICEF, in collaboration with their networks and partners, have published a ground-breaking manual and accompanying tools for analysts who conduct social listening to develop infodemic insights. What makes this manual unique is that it emphasizes an evidence-based and reproducible process performing integrated analysis across online and offline datasets to produce infodemic insights and recommendations for action to improve public health.