Doha, Qatar: A groundbreaking case study on monogenic obesity by the Endocrinology Department at Sidra Medicine, a member of Qatar Foundation, has been published in the prestigious New England Journal of Medicine.

 Monogenic obesity is a rare, early-onset, and severe form of obesity resulting from a mutation or deficiency of a single gene. It is caused by changes in the leptin, a hormone the body releases that helps it maintain your normal weight. Children affected by monogenic obesity generally experience delayed pubertal development, and recurrent severe infections. They often show a decreased sensation of satiety in early childhood and suffer from a constant feeling of hunger.