This report developed by UNAIDS and the United for Global Mental Health reviews and maps Global Fund investments in priority HIV and TB comorbidities in Grant Cycle 7 (GC7), including key non-communicable diseases (NCDs), cervical,  anorectal and other cancers, and mental health and substance use conditions.  It highlights how countries prioritize and are integrating health services and other interventions with HIV and TB programmes to advance person-centered approaches and to sustain HIV and TB responses. Analyzing approved grants from 103 countries, the report finds strong demand for integrated approaches, with 97% of countries prioritizing at least one comorbidity.  However, it also reveals major funding gaps, limited allocation compared to identified needs, and weaknesses in monitoring and accountability for integrated approaches, services and systems. The report concludes with practical recommendations to protect and scale evidence-informed and rights-based integrated systems, services and other interventions for addressing comorbidities, strengthen performance and outcome measurement, embed community engagement in decision-making, budgeting, performance monitoring and direct integrated service delivery, and reposition technical assistance, offering clear guidance for shaping sustained partnership, strategic investment, and collective commitment to strengthen systems for health and enhance integrated service delivery for more sustainable HIV and TB responses, and ensuring the health and well-being of people living with and at risk of HIV or TB.