In this study, 211 pesticides were analyzed simultaneously using a QuEChERS method coupled with GC–MS–MS and LC–MS–MS in 90 fresh date fruit samples produced in Kerman Province. Probabilistic estimates of non-carcinogenic and carcinogenic health risks were evaluated using Monte Carlo simulation-based hazard Quotient (HQ), hazard index (HI) and carcinogenic risk (CR). The linearity of 0.015–0.30 mg kg−1 with the coefficient of determination (R2) values exceeding 0.9989 were achieved. The percentage of recoveries, limits of detection (LODs), limits of quantification (LOQs), Relative standard deviation (RSD %) and matrix effect (ME) were determined in the range of 77–119%, 0.001–0.003 mg kg−1 and 0.005–0.01 mg kg−1, ≤ 15% and − 7.5 to 14.2%, respectively. Among 90 analyzed date fruits, 9 samples (10%) contained at least one pesticide residue, whereas 5 samples (5.5%) showed pesticide residues exceeding maximum residual limit (MRL) according to the national and European Commission. The obtained HQ values for the target pesticides were as cypermethrin > imazalil > permethrind > endosulfan > Fenpropathrin. The HI values for adult and child consumers with all pesticide residues were lower than 1. The CR was less than 1.0E-6 value. Thus, there was no carcinogenic risk to the consumers of date fruits.