The final results of a landmark study published in The Lancet Infectious Diseases confirm that the benefits of combining the RTS,S/AS01E (RTS,S) malaria vaccine with antimalarial drugs in settings of highly seasonal malaria transmission continue over five years. The vaccine-drug combination reduced clinical malaria episodes, including cases of severe malaria, and deaths from malaria in young children by nearly two-thirds compared with either RTS,S vaccination or seasonal malaria chemoprevention (SMC) alone.