To coordinate, support, monitor, and evaluate the implementation of the African Union One Health Strategy for Zoonotic Disease Prevention and Control across the Member States, the African Union Interagency Group on One Health has been established. The Interagency was established during a meeting on One Health that took place from 13-14 June 2022 at AU-IBAR in Nairobi, Kenya. The Interagency comprises several AU offices that have been mandated to deal with various aspects of human/ animal health interventions, namely: The Africa Centre for Disease Control and Prevention (Africa CDC); The African Union InterAfrican Bureau for Animal Resources (AU-IBAR); The Scientific, Technical and Research Commission (STRC); The Department of Agriculture, Rural Development and Blue Economy (DARBE); The Department of Health, Humanitarian Affairs, and Social Development (HHS); the InterAfrican Phytosanitary Council (AU-IAPSC); and the Citizens and Diaspora Organizations (CIDO).