Afghanistan faces major challenges in healthcare access due to decades of conflict, geographic isolation, and limited infrastructure. Telemedicine presents a promising solution to bridge these gaps by leveraging technology to connect healthcare providers and patients across distances and time zones. This review explores the current landscape of telemedicine in Afghanistan, synthesizing evidence from published studies, program evaluations, and implementation reports across multiple specialties and healthcare settings. Telemedicine initiatives in the country span critical care, mental health, ophthalmology, general medicine, and emergency services, extending their benefits to both urban and rural populations. Key programs include the Central Asia Health Systems Strengthening (CAHSS) Project (6,140 teleconsultations), tele-ICU services (6,014 consultations showing reduced mortality), mental health interventions in remote provinces, and military teleophthalmology programs. Despite notable barriers such as limited Internet connectivity, unreliable electricity, regulatory gaps, cultural resistance, low digital literacy, and workforce shortages, telemedicine has improved access to care, strengthened provider capacity, reduced stigma, and demonstrated high patient satisfaction and cost-effectiveness, particularly in underserved regions. Overall, telemedicine represents a viable and effective strategy for enhancing healthcare delivery in Afghanistan. Continued progress will depend on sustained investment in digital infrastructure, supportive policy frameworks, workforce development, community engagement, and robust monitoring systems. Further research should focus on longitudinal evaluations, national registries, and comprehensive cost-effectiveness analyses to inform future telemedicine expansion and sustainability.