Around the world each year, tens of millions of people are told they have cancer, and millions die from the disease. Now, a report from the American Cancer Society projects that by 2050, the number of people with cancer could rise 77%.

The report, published Thursday in the journal CA: A Cancer Journal for Clinicians, found that in 2022 – the most recent year for which data was available – about 20 million cases of cancer were diagnosed alongside 9.7 million deaths from cancer.

Those estimates suggest that about 1 in 5 people who are alive now will develop cancer in their lifetime, and around 1 in 9 men and 1 in 12 women will die from the disease.

The new report says population growth and aging are key drivers of the size of the world’s cancer burden, with the global population of about 8 billion people in 2022 projected to reach 9.7 billion by 2050.