Background: Work in intensive care units (ICU) is associated with high levels of stress, which can result in reduced productivity and compromised health care quality, if not managed appropriately. The Health and Safety Executive (HSE) has developed the Management Standards Indicator Tool (IT) that includes the six HSE Management Standards; demands (workload, work patterns and environment), control (how much say a person has in the way they work), manager support (encouragement, sponsorship, resources provided by organization/line management) and peer support (encouragement and resources from colleagues), workplace relationships (promoting positive working to avoid conflict and deal with unacceptable behavior), roles (whether people understood their role), and change (how organizational change is managed). This study aimed to assess occupational stress and identify the major management standards indicators of organizational psychosocial hazard exposure among ICU nurses in public hospitals in Jazan, Saudi Arabia, using the HSE-IT for occupational stress.