In 1983, pioneering AIDS activists agreed the Denver Principles manifesto, which rejected the notion that people living with HIV were victims and made it clear that they had a central role to play in all aspects of the AIDS response. This was an historic first step towards the Greater Involvement of People with HIV (GIPA) principle, which promotes the meaningful participation of people living with HIV. That principle, where communities lead, has guided significant strides forward. That is reflected in the fact that the number of people on antiretroviral treatment worldwide rose almost fourfold, from 7.7 million in 2010 to 29.8 million in 2022. Yet every minute in 2022, AIDS claimed a life and 9.2 people living with HIV did not have access to treatment. Unfortunately, rates of new infections and deaths are not falling rapidly enough to meet the Sustainable Development Goal target to end AIDS as an epidemic by the end of this decade.