Neglected tropical diseases (NTDs) generally most impact the poor in low-income regions. The “neglected” aspect of NTDs refers to their absence from the global health agenda resulting in limited funding from international agencies. A focused and concerted effort in improving the quality of healthcare in the most NTD-affected regions could have a huge positive impact in improving lives, yet these efforts are often hampered by a low level of awareness. Typically, when we think of NTDs dengue fever, leishmaniasis or even rabies are at the forefront of the public consciousness. This month we use our Editorial to bring awareness to Chagas disease (CD), one of the more neglected of the NTDs and the subject of April’s WHO awareness day.